Big Picture Education Australia: Experiences of students, parents/carers & teachers

Too many young Australians, especially those from disadvantaged circumstances, are not benefiting from the rewards of education and training. For others, there is a growing sense of frustration and alienation about the kind of education they receive, and from their point of view school is boring, irrelevant and disconnected from the world they know. For many, there is a lack of personal connectedness and meaning as their own needs, desires, aspirations and interests are denied in large high school settings where the focus is on subjects, timetables, discipline, didactic teaching, examinations, and classroom-based learning. These historically persistent and protracted problems have preoccupied policymakers, researchers and school reformers for the past sixty years or more. Whilst hardly new, the issue of student (dis)engagement is an increasingly urgent public policy matter not only in terms of economics - cost, productivity, global competitiveness, innovation and human capital, but also social cohesion, mental health and wellbeing, social justice, and democracy itself. At a time when young people face an increasingly volatile and uncertain future due to the impact of globalisation, deindustrialisation, technology, and job insecurity, schools are under pressure to resolve some complex social, economic and political problems not always of their own making. Ironically, schools are often perceived to be a part of the problem and also the solution. Against this broader backdrop, this report attempts to identify, map and describe the experiences of students, their parents/carers and teachers attending schools in a range of sites across Australia adopting an interest-based approach to learning. The intent is to illuminate the experiences of these participants and, from their vantage point, better understand how this approach might address questions of student engagement, school reform, school leadership, curriculum, organisation, assessment and school-community relationships

Promising practices: What students, parents and teachers say about learning in a Big Picture context

This report identifies the key findings from a research project into the early implementation (the first 20 months) of the Big Picture Education (BPE) design for learning and school 1 in five different schools in Western Australia. The aim was to understand better how student engagement for learning and aspirations develop in a Big Picture context. These findings are reported more extensively in a series of Research Briefs, Combined Reports and papers. 2 Our goal in this document is to bring the findings together into the one summary report

Polonium-210 poisoning: a first-hand account

Background: Polonium-210 (210Po) gained widespread notoriety after the poisoning and subsequent death of Mr Alexander Litvinenko in London, UK, in 2006. Exposure to 210Po resulted initially in a clinical course that was indistinguishable from infection or exposure to chemical toxins, such as thallium. Methods: A 43-year-old man presented to his local hospital with acute abdominal pain, diarrhoea, and vomiting, and was admitted to the hospital because of dehydration and persistent gastrointestinal symptoms. He was initially diagnosed with gastroenteritis and treated with antibiotics. Clostridium difficile toxin was subsequently detected in his stools, which is when he first raised the possibility of being poisoned and revealed his background and former identity, having been admitted under a new identity with which he had been provided on being granted asylum in the UK. Within 6 days, the patient had developed thrombocytopenia and neutropenia, which was initially thought to be drug induced. By 2 weeks, in addition to bone marrow failure, he had evidence of alopecia and mucositis. Thallium poisoning was suspected and investigated but ultimately dismissed because blood levels of thallium, although raised, were lower than toxic concentrations. The patient continued to deteriorate and within 3 weeks had developed multiple organ failure requiring ventilation, haemofiltration, and cardiac support, associated with a drop in consciousness. On the 23rd day after he first became ill, he suffered a pulseless electrical activity cardiorespiratory arrest from which he could not be resuscitated and was pronounced dead. Findings: Urine analysis using gamma-ray spectroscopy on day 22 showed a characteristic 803 keV photon emission, raising the possibility of 210Po poisoning. Results of confirmatory analysis that became available after the patient's death established the presence of 210Po at concentrations about 109-times higher than normal background levels. Post-mortem tissue analyses showed autolysis and retention of 210Po at lethal doses in several organs. On the basis of the measured amounts and tissue distribution of 210Po, it was estimated that the patient had ingested several 1000 million becquerels (a few GBq), probably as a soluble salt (eg, chloride), which delivered very high and fatal radiation doses over a period of a few days. Interpretation: Early symptoms of 210Po poisoning are indistinguishable from those of a wide range of chemical toxins. Hence, the diagnosis can be delayed and even missed without a high degree of suspicion. Although body surface scanning with a standard Geiger counter was unable to detect the radiation emitted by 210Po, an atypical clinical course prompted active consideration of poisoning with radioactive material, with the diagnosis ultimately being made with gamma-ray spectroscopy of a urine sample

Investigation of a bicyclo[1.1.1]pentane as a phenyl replacement within an LpPLA2 inhibitor

We describe the incorporation of a bicyclo[1.1.1]pentane moiety within two known LpPLA2 inhibitors to act as bioisosteric phenyl replacements. An efficient synthesis to the target compounds was enabled with a dichlorocarbene insertion into a bicyclo[1.1.0]butane system being the key transformation. Potency, physicochemical, and X-ray crystallographic data were obtained to compare the known inhibitors to their bioisosteric counterparts, which showed the isostere was well tolerated and positively impacted on the physicochemical profile

ARK: Autonomous mobile robot in an industrial environment

This paper describes research on the ARK (Autonomous Mobile Robot in a Known Environment) project. The technical objective of the project is to build a robot that can navigate in a complex industrial environment using maps with permanent structures. The environment is not altered in any way by adding easily identifiable beacons and the robot relies on naturally occurring objects to use as visual landmarks for navigation. The robot is equipped with various sensors that can detect unmapped obstacles, landmarks and objects. In this paper we describe the robot's industrial environment, it's architecture, a novel combined range and vision sensor and our recent results in controlling the robot in the real-time detection of objects using their color and in the processing of the robot's range and vision sensor data for navigation

TGFβ inhibition stimulates collagen maturation to enhance bone repair and fracture resistance in a murine myeloma model

Multiple myeloma is a plasma cell malignancy that causes debilitating bone disease and fractures, in which TGFβ plays a central role. Current treatments do not repair existing damage and fractures remain a common occurrence. We developed a novel low tumour phase murine model mimicking the plateau phase in patients, as we hypothesized this would be an ideal time to treat with a bone anabolic. Using in vivo microCT we show substantial and rapid bone lesion repair (and prevention) driven by SD‐208 (TGFβ receptor I kinase inhibitor) and chemotherapy (bortezomib and lenalidomide) in mice with human U266‐GFP‐luc myeloma. We discovered that lesion repair occurred via an intramembranous fracture repair‐like mechanism and that SD‐208 enhanced collagen matrix maturation to significantly improve fracture resistance. Lesion healing was associated with VEGFA expression in woven bone, reduced osteocyte‐derived PTHrP, increased osteoblasts, decreased osteoclasts and lower serum TRACP‐5b. SD‐208 also completely prevented bone lesion development mice with aggressive JJN3 tumors, and was more effective than an anti‐TGFβ neutralizing antibody (1D11). We also discovered that SD‐208 promoted osteoblastic differentiation (and overcame the TGFβ‐induced block in osteoblastogenesis) in myeloma patient bone marrow stromal cells in vitro, comparable to normal donors. The improved bone quality and fracture‐resistance with SD‐208 provides incentive for clinical translation to improve myeloma patient quality of life by reducing fracture risk and fatality

稲垣足穂『少年愛の美学』の読書論的研究 --念者としての語り--

千葉大学大学院人文社会科学研究科研究プロジェクト報告書第144集 『パフォーマンスの民族誌的研究』橋本裕之

Genome-wide DNA methylation analysis for diabetic nephropathy in type 1 diabetes mellitus

BACKGROUND: Diabetic nephropathy is a serious complication of diabetes mellitus and is associated with considerable morbidity and high mortality. There is increasing evidence to suggest that dysregulation of the epigenome is involved in diabetic nephropathy. We assessed whether epigenetic modification of DNA methylation is associated with diabetic nephropathy in a case-control study of 192 Irish patients with type 1 diabetes mellitus (T1D). Cases had T1D and nephropathy whereas controls had T1D but no evidence of renal disease. METHODS: We performed DNA methylation profiling in bisulphite converted DNA from cases and controls using the recently developed Illumina Infinium(R) HumanMethylation27 BeadChip, that enables the direct investigation of 27,578 individual cytosines at CpG loci throughout the genome, which are focused on the promoter regions of 14,495 genes. RESULTS: Singular Value Decomposition (SVD) analysis indicated that significant components of DNA methylation variation correlated with patient age, time to onset of diabetic nephropathy, and sex. Adjusting for confounding factors using multivariate Cox-regression analyses, and with a false discovery rate (FDR) of 0.05, we observed 19 CpG sites that demonstrated correlations with time to development of diabetic nephropathy. Of note, this included one CpG site located 18 bp upstream of the transcription start site of UNC13B, a gene in which the first intronic SNP rs13293564 has recently been reported to be associated with diabetic nephropathy. CONCLUSION: This high throughput platform was able to successfully interrogate the methylation state of individual cytosines and identified 19 prospective CpG sites associated with risk of diabetic nephropathy. These differences in DNA methylation are worthy of further follow-up in replication studies using larger cohorts of diabetic patients with and without nephropathy

Modelling the orientation of accretion disks in quasars using H-alpha emission

Infrared spectroscopy of the H-alpha emission lines of a sub-sample of 19 high-redshift (0.8 < z < 2.3) Molonglo quasars, selected at 408 MHz, is presented. These emission lines are fitted with composite models of broad and narrow emission, which include combinations of classical broad-line regions of fast-moving gas clouds lying outside the quasar nucleus, and/or a theoretical model of emission from an optically-thick, flattened, rotating accretion disk. All bar one of the nineteen sources are found to have emission consistent with the presence of an optically-emitting accretion disk, with the exception appearing to display complex emission including at least three broad components. Ten of the quasars have strong Bayesian evidence for broad-line emission arising from an accretion disk together with a standard broad-line region, selected in preference to a model with two simple broad lines. Thus the best explanation for the complexity required to fit the broad H-alpha lines in this sample is optical emission from an accretion disk in addition to a region of fast-moving clouds. We derive estimates of the angle between the rotation axis of the accretion disk and the line of sight. A weak correlation is found between the accretion disk angle and the logarithm of the low-frequency radio luminosity. This is direct, albeit tenuous, evidence for the receding torus model. Velocity shifts of the broad H-alpha components are analysed and the results found to be consistent with a two-component model comprising one single-peaked broad line emitted at the same redshift as the narrow lines, and emission from an accretion disk which appears to be preferentially redshifted with respect to the narrow lines for high-redshift sources and blueshifted relative to the narrow lines for low-redshift sources.Comment: The definitive version is available at www.blackwell-synergy.com. 36 pages, 21 figures, 13 tables. Replaced to fix A4/US letter paper size confusio